Class Of Nuke 'Em High is the story of a group of high school students who are looking to get their fix of illegal drugs. The find an unlikely dealer at a nearby nuclear power plant, but it is not known that the drugs have been altered by the radioactive material in the power plant. When they take the drugs, the students begin to see subtle changes in their body and behavior. This is especially true for Chrissy (Janelle Brady) who is pregnant with the child of Warren (Gil Brenton), another student who took the drugs. Chrissy ends up giving birth to horrible mutant who rapidly grows to an enormous size and begins terrorizing the school.