Kagome Higurashi has been told many stories by her grandfather, such as the one about the Shikon no Tama (The Jewel of Four Souls) and never believed them until her fifteenth birthday, when she is pulled down a dry well at her shrine by a centipede demon. She emerges from the well to discover she's not in Tokyo any more, but instead, she's in in Feudal Japan.Kagome discovers a weird boy with dog ears pinned to a tree in a forest and is captured by strange villagers. The high priestess of the village, Kaede, realizes that Kagome looks just like her sister who died 50 years ago.

Inuyasha attacks Kagome to get the Shikon no Tama. Kaede puts a rosary on Inuyasha which causes him to drop to the ground that whenever Kagome utters the word "sit". When trying to get the Shikon no Tama back from a demon that steals it, Kagome accidentally shatters it into hundreds of pieces that are scattered all over Japan!

After Inuyasha angers her, Kagome decides to return home to the present. At the well, she is attacked by Yura, a demon who is after the Shikon no Tama.

Inuyasha brings Kagome back to the past, and the two team up to take the Shikon shard back from Yura.

Inuyasha's older brother, Sesshomaru, who is a full demon, crosses paths with Inuyasha in his search for the powerful sword that was left behind by their father.

Sesshomaru continues his scheme of getting Inuyasha to reveal the location of their father's grave.

Sesshomaru and Inuyasha clash over possession of the Tetsusaiga. Who will be victorious in this epic fight between these two siblings?

On their search for Shikon jewel shards, Inuyasha and Kagome come across Amari Nobunaga, who is on a search and rescue mission for his beloved Princess Tsuyu.

Inuyasha and Kagome meet a fox demon named Shippo. The young fox explains that he is looking for jewel shards so he can become strong enough to fight the Thunder Brothers, Hiten and Manten. Inuyasha soon goes to face off against the brothers for the jewel shards that they possess.

Inuyasha and Hiten engage in a fierce battle for the jewel shards, while Kagome and Shippo face off against Manten.

Kagome returns home to study for a test. Meanwhile, inside the storehouse on the Higurashi shrine grounds, an evil Noh mask that was sealed away a long time ago awakens.

Kagome helps a troubled ghost move on.

Inuyasha, Kagome and Shippo are looking for more jewel shards, when they help out a girl running from a demon. Kagome wants to stay the night at the temple she lives in, but Inuyasha wants to keep moving. In the end, they agree to stay. Later that night, demons surround the temple, and Inuyasha prepares to fight them.

Kikyo's ashes are stolen from her grave by the demon Urasue. As Kaede, Inuyasha, Kagome and Shippo go to retrieve them, Kagome realizes that Inuyasha and Kikyo were once in love! Meanwhile, with Kikyo's ashes, Urasue manages to resurrect Kikyo. However, she finds that Kikyo cannot move without her soul: the very soul that is inside of Kagome!

Now that Urasue has kidnapped Kagome, she prepares for the soul transfer, which Inuyasha unknowingly activates. Once the soul is transferred, Kikyo attacks Inuyasha. Inuyasha learns of his supposed betrayal of Kikyo, 50 years ago. Kagome soon reclaims her soul and Kikyo runs off to retain at least part of it Inuyasha chases after and thinks back to when Kikyo convinced him to use the Shikon no Tama, to become Human!

Inuyasha, Kagome and Shippo cross paths with Miroku, a lecherous monk with a "black hole" in his right hand. Miroku explains that his black hole (Wind Tunnel) came from the evil Naraku, an extremely evil shapeshifter who cursed his grandfather and his descendents with the Wind Tunnel. Inuyasha also learns something new about what happened to him and Kikyo, long ago.

Inuyasha and the others become entangled with an odd painter who has been corrupted by the power of a Shikon shard.

The one-armed Sesshomaru receives a Shikon-enhanced arm with which to wield Tetsusaiga from a mysterious man, wearing a baboon cloak, named Naraku. This leads Sesshomaru to go after Inuyasha, once more.

After a badly beaten Inuyasha gets ahold of Tetsusaiga once more, Sesshomaru backs off. Convinced that Kagome doesn't belong in the past, Inuyasha takes her to the well, hugs her close, takes her shards, and pushes her back through, to the present time.

Kaede informs the group of Onigumo, a paralyzed bandit who had an unhealthy obsession with Kikyo, and tells them of his sudden disappearance. The group then has to deal with an attack by the Shikon-induced Royakan!

As Kagome goes on a date with Hojo, all hell breaks loose in the past as Inuyasha battles with Royakan. When Naraku reveals himself to the group his true identity is soon discovered!

Since Kagome reclaimed most of her soul, Kikyo now walks the land and steals the souls from young girls. This act inadvertently leads Kagome and Inuyasha right to her!

Inuyasha goes to meet with Kikyo. Kagome, Miroku and Shippo are waiting for him to return, when they see some soul collectors. They decide to chase after them.

After her family is murdered in front of her eyes, the demon slayer Sango learns from Naraku that her village was destroyed by Inuyasha.

Believing that Inuyasha destroyed her village, Sango goes after Inuyasha.

Sango shows the group where the Shikon no Tama was created, thus revealing the story of its origin.

When a water god starts demanding child sacrifices, it's up to Inuyasha and the others to stop him.