Van Helsing (Hugh Jackman) is sent by the Vatican, with his trusty assistant Carl (David Wenham), to Transylvania to battle Dracula (Richard Roxburgh) and his brides Aleera (Elena Anaya), Verona (Silvia Colloca) and Marishka (Josie Maran) from using the strength of Frankenstein's monster to bring their hideous offspring to life. Along the way Van Helsing is helped by the beautiful Anna Valerious (Kate Beckinsale) to vanquish Dracula. Something she must achieve if she is to free her family from a dreadful oath that stops them from entering heaven if Dracula isn't defeated by a member of the Valerious family.