Agent Neville Flynn (Samuel L. Jackson) is assigned to accompany and protect murder witness Nathan Phillips (Sean Jones) on a flight from Hawaii to Los Angeles. Someone wants Phillips dead, of course. Instead of just killing him, the mystery assassin has placed boxes full of deadly snakes that are programmed to open and release the snakes at a specific time during the flight in the cargo hold of the plane. These aren't just ordinary deadly poisonous snakes either; these snakes have been given a substance that makes them crazy! Snakes gone wild! This is not a serious action film. Twisted humor is what drives "Snakes on a Plane." A guy is ferociously bitten while taking a leak... on the one place he'd least like to be bitten. A small dog is swallowed by a giant boa constrictor. Dozens of deadly snakes are attacking passengers all within the confines of a commercial jet. Who's going to land this plane?